David Video - Transcript
VO: Please watch important safety information throughout and at the end of this VIDEO and see accompanying full prescribing information, including medication guide, which is also available at www dot rxAbbVie dot com
Text on screen: A Patient’s Journey. Please watch Important Safety Information throughout and at the end of this video and see accompanying full Prescribing Information, including Medication Guide, which is also available at www.rxabbvie.com/pdf/duopa_pi.pdf
Text on screen: DUOPA (carbidopa and levodopa) enteral suspension is a prescription medicine used for the treatment of advanced Parkinson’s disease. Please watch Important Safety Information throughout and at the end of this video and see accompanying full Prescribing Information, including Medication Guide, which is also available at www.rxabbvie.com/pdf/duopa_pi.pdf
VO: This is the story of one PATIENT, and individual experiences may vary with Duopa (carbidopa and levodopa). Only you and your doctor can decide if Duopa is right for you. Your doctor is your best resource for medical information.
Text on screen: This is the story of one patient, and individual experiences may vary with Duopa (carbidopa and levodopa). Only you and your doctor can decide if Duopa is right for you. Your doctor is your best resource for medical information. Please watch Important Safety Information throughout and at the end of this video and see accompanying full Prescribing Information, including Medication Guide, which is also available at www.rxabbvie.com./pdf/duopa_pi/pdf
Text on screen: David’s Journey with Duopa
David: Tremors to me, I think you’ll see, this would be an EXAMPLE: my legs are going to start to shake as I'm “off”–like this. My toes are going to be curling into a fist, a little mini fist down there. I’ll get this kind of effect on the hands. With pills, it’s always a constant challenge to get the pills to work going down your digestive system. It’s a really challenging situation.
My name is Dave.
I live in the state of Florida, and I was first diagnosed with Parkinson’s in 2011. I did wind up spending almost 17 years in the Air Force, repairing airplanes as enlisted, then repairing airplanes as an officer. “Off” time is, over the years it varies, but right now, to me, “off” time is unbalanced and falls.
David: There’s not many options for me. Pills or Duopa. Pills are easier.
However, those fluctuations are really, over time they’re terrible, to have the on and off symptoms. So having the Duopa is just amazing. It’s what I want to experience and see how it truly works. That’s why I’m excited about that.
Text on screen:
Treatment Facility
Orlando, Florida
Dr. Rodriguez: My name is Ramon Rodriguez, and I am a movement disorders neurologist. What I realized immediately is that David was in an advanced stage of Parkinson’s disease. So he was having at least three hours that he was in the “off” medication state, minimum, despite taking the medication six times per day and taking the medication at a very large dose.
Not only was he spending a lot of “off” time, but when he was “on,” it was not a quality “on” because of the severity of the dyskinesia.
Text on screen:
December 2023: Titration Day
1 week prior to starting therapy with Duopa, David had a surgical procedure.*
*A PEG-J (percutaneous endoscopic gastronomy with jejunal tube) procedure is required to make a small hole (“stoma”) in your stomach. Duopa is delivered continuously into your small intestine by a pump for up to 16 hours a day. David has this procedure a week prior to starting therapy.
Dr. Rodriguez: So the reason why we’re doing this Duopa is because we have some data; we have done a lot of research that tells us that we might be able to provide you the right amount of the medication so you stay in the “on” medication state. And the “on” medication state is when you're able to move around. Everything understood? There you go. All right, brother.
Dr. Rodriguez: All right, David. So it's been now a little bit of time. We’re about an hour and a half.
David: I’m starting to feel... a different kind of feeling. I mean, this is new to me. And I’m feeling better. I’m used to the pills. It’s all a different process. This is so new. It’s hard to process it in a way. But I do feel more freedom of movement right now. You know, I know this product here is going to change so many people’s lives.
Thank you, doctor. I appreciate you doing this. Thank you.
Dr. Rodriguez: We’re in this together. We’re in this together. That’s right.
Text on screen:
One Month Later
Change in “off” time was measured at 12 weeks in the Duopa clinical trials
David: For 16 hours, I have a steady dose of carbidopa/levodopa going through me. It’s not a miracle drug. Nothing like that. What it is, is it gives you a slow, steady dose, but there are some peaks and valleys. So, you experiment with it and find out what works for you. Adopt it and use it. Duopa has definitely allowed me a little bit more “on” time. And I appreciate that because pills, in a nutshell, are not really doing it. And having this as a resource and a therapy is doing it.
And so, I want to keep this. I want to stick around. It’s on autopilot. This thing is, it takes care of itself. You just have to turn it on and set it and forget it. That’s what it is. It’s set and forget. And let it do its thing. Let it do its work, its therapy. And that’s awesome. I mean, that’s awesome.
Text on screen: There are detailed steps required to properly store, prepare and administer Duopa. Keep a supply of oral carbidopa/levodopa tablets in case you are unable to use the infusion. Refer to the Full Instructions for Use.
Text on screen: In a study, patients on Duopa had nearly 2 hours less “off” time at 3 months compared to patients on oral immediate-release (IR) carbidopa/levodopa.*
*The study included 71 people with advanced Parkinson’s disease. It evaluated the safety and efficacy of Duopa compared to immediate-release oral CD/LD over 12 weeks.
Text on screen: David was on prescribed Duopa therapy at the time of providing a testimonial. Changes in therapy may have occurred since that time. Please continue to watch for Important Safety Information.
TEXT ON-SCREEN and VO:
USE
DUOPA (carbidopa and levodopa) enteral suspension is a prescription medicine used for treatment of advanced Parkinson’s disease. DUOPA contains two medicines: carbidopa and levodopa.
IMPORTANT SAFETY INFORMATION
What is the most important safety information I should know about DUOPA?
- Stomach and intestine (gastrointestinal) problems and problems from the procedure you will need to have to receive DUOPA (gastrointestinal procedure-related problems) may occur. Some of these problems may require surgery and may lead to death.
- Serious side effects may include: a blockage of your stomach or intestines (bezoar); stopping movement through intestines (ileus); drainage, redness, swelling, pain, feeling of warmth around the small hole in your stomach wall (stoma); bleeding from stomach ulcers or your intestines; inflammation of your pancreas (pancreatitis); infection in your lungs (pneumonia); air or gas in your abdominal cavity; skin infection around the intestinal tube, pocket of infection (abscess), or infection in your blood (sepsis) or abdominal cavity may occur after surgery; stomach pain, nausea, or vomiting.
- Tell your healthcare provider right away if you have any of the following symptoms of stomach and intestine problems and gastrointestinal procedure-related problems: stomach (abdominal) pain; constipation that does not go away; nausea or vomiting; fever; blood in your stool; or a dark tarry stool.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using DUOPA with certain other medicines, including medications for high blood pressure, MAO inhibitors, antipsychotics, metoclopramide, isoniazid, and iron or vitamin supplements, may cause serious side effects. High-protein foods may affect how DUOPA works. Tell your healthcare provider if you change your diet.
DUOPA may cause serious side effects. Talk to your doctor before starting DUOPA and while on DUOPA if you have had or have any of these:
- Falling asleep during normal daily activities without warning. DUOPA may cause you to fall asleep while you are doing daily activities such as driving, which may result in an accident. This can happen as late as one year after starting DUOPA. Do not drive or operate machinery until you know how DUOPA affects you. Tell your healthcare provider if you take medicines that can make you sleepy, such as sleep medicines, antidepressants, or antipsychotics.
- Low blood pressure when you stand or sit up quickly. After you have been sitting or lying down, stand up slowly to help reduce dizziness, nausea, sweating, or fainting until you know how DUOPA affects you.
- Seeing, hearing, or feeling things that are not real (hallucinations).
- Unusual urges. Some people taking medicines for Parkinson’s disease, including DUOPA, have reported urges such as excessive gambling, compulsive eating, compulsive shopping, and increased sex drive.
- Depression and suicide. DUOPA can cause or worsen depression. Pay close attention to changes in your mood, behavior, thoughts, or feelings. Call your healthcare provider right away if you feel depressed or have thoughts of suicide.
- Uncontrolled sudden movements (dyskinesia). If you have new dyskinesia or your dyskinesia gets worse, tell your healthcare provider. This may be a sign that your dose of DUOPA or other Parkinson’s medicines may need to be adjusted.
- Progressive weakness or numbness or loss of sensation in the fingers or feet (neuropathy).
- Heart attack or other heart problems. Tell your healthcare provider if you have experienced increased blood pressure, a fast or irregular heartbeat, or chest pain.
- Abnormal blood tests. DUOPA may cause changes in certain blood tests, especially certain hormone and kidney function blood tests.
- Worsening of the increased pressure in your eyes (glaucoma). The pressure in your eyes should be checked after starting DUOPA.
Do not stop using DUOPA or change your dose unless you are told to do so by your healthcare provider. Tell your healthcare provider if you develop withdrawal symptoms such as fever, confusion, or severe muscle stiffness.
The most common side effects of DUOPA include: complications of tubing placement procedure, swelling of legs and feet, nausea, high blood pressure (hypertension), depression, and mouth and throat pain.
Please see the full Prescribing Information including Medication Guide for additional information about DUOPA. Talk to your healthcare provider if you have questions.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/myAbbVieAssist to learn more.
Text on screen: © 2024 AbbVie Inc. North Chicago, Illinois, U.S.A. US-DUOP-240031 May 2024